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|The research focus of our
laboratory is on the neuroscience of human emotion and
affective disorders. One of our primary research goals is to determine the neurobiological
substrates of heterogeneity in anxiety and depression. Our studies use clinical and
nonclinical samples and employ an array of methodologies including fMRI, EEG, eye-blink
startle, neuropsychological tasks, cortisol, and autonomic psychophysiology. We have
developed laboratory-based models of anticipatory and reactivity processes elicited
by emotional stimuli. Building on this work, we are currently examining the placebo
effect as a function of expectancy. Another major interest of ours is the neural
circuitry of positive emotion, with our fMRI research in this area employing novel
paradigms for inducing potent positive emotions.
Jack B. Nitschke
Associate Professor, Departments of Psychiatry and Psychology
Ph.D. 1998, University of Illinois at Urbana-Champaign
Nitschke, J.B., Sarinopoulos, I., Mackiewicz, K.L., Schaefer, H.S., & Davidson, R.J.
(in press). Functional neuroanatomy of aversion and its anticipation. NeuroImage.
Nitschke, J.B., Nelson, E.E., Rusch, B.D., Fox, A.S., Oakes, T.R., & Davidson, R.J.
(2004). Orbitofrontal cortex tracks positive mood in mothers viewing pictures of their infants.
NeuroImage, 21, 583-592.
Nitschke, J.B., Heller, W., Etienne, M.A., & Miller, G.A. (2004). Prefrontal cortex activation
differentiates processes affecting memory in depression. Biological Psychology, 67, 125-143.
Nitschke, J.B., & Heller, W. (2002). The neuropsychology of anxiety disorders: Affect, cognition,
and neural circuitry. In H. DíHaenen, J.A. den Boer, & P. Willner (Eds.), Biological psychiatry
(pp. 975-988). Chichester, UK: John Wiley & Sons, Ltd.
Nitschke, J.B., Larson, C.L., Smoller, J.J., Navin, S. D., Pederson, A.J.C., Ruffalo,
D., Mackiewicz, K.L., Gray, S.M., Victor, E., & Davidson, R.J. (2002). Startle potentiation
in aversive anticipation: Evidence for state but not trait effects. Psychophysiology, 39, 254-258.
Nitschke, J.B., Heller, W., Imig, J.C., McDonald, R.P., & Miller, G.A. (2001). Distinguishing
dimensions of anxiety and depression. Cognitive Therapy and Research, 25, 1-22.
Nitschke, J.B., Heller, W., Palmieri, P.A., & Miller, G.A. (1999). Contrasting patterns of
brain activity in anxious apprehension and anxious arousal. Psychophysiology, 36, 628-637.