Professor, Department of Psychology
Ph.D. 1988, University of Florida
My research focuses on the modulatory actions of neurotransmitters, particularly catecholamines and select neuropeptides, in the regulation of behavioral state and state-dependent cognitive processes (working memory, attention). We take a multidisciplinary approach that includes anatomical, neurochemical, behavioral, electrophysiological and computational methods. This includes studies that examine the effects of cognitive enhancers (Ritalin/methylphenidate) and stress on the electrophysiological activity of neurons within PFC and frontostriatal networks in animals engaged in PFC-dependent cognitive tasks.
Currently there are 3 main themes:
- The Neurobiology of Cognitive Enhancers used in the Treatment of ADHD (primarily psychostimulants such as methylphenidate/Ritalin);
- The Neurobiology of Arousal and the Neural Mechanisms of Psychostimulant-Induced Arousal.
- The Neurobiology of Stress and Stress-Related Cognitive Impairment.
Berridge CW and Foote SL (1991) Effects of locus coeruleus activation on electroencephalographic activity in neocortex and hippocampus.
Journal of Neuroscience, 11:3135-3145.
Berridge CW and Foote SL (1996) Enhancement of behavioral, electroencephalographic (EEG), and electromyographic (EMG) indices of waking following stimulation of noradrenergic β-receptors located within the medial septal region of the basal forebrain in the unanesthetized rat. Journal of Neuroscience, 16:6999-7009.
España RA, Baldo B, Kelley AE, Berridge CW (2001) Wake-Promoting and Sleep-Suppressing Actions of Hypocretin (Orexin): Basal Forebrain Sites of Action. Neuroscience, 106:699-715.
Berridge CW and Waterhouse BD (2003) Modulatory Actions of the Locus Coeruleus-Noradrenergic System on Behavioral State and State-Dependent Cognitive Processes. Brain Research Review, 42:33-84.
España RA, Valentino RJ, and Berridge CW (2003) Fos immunoreactivity in hypocretin-synthesizing and hypocretin 1-receptor-expressing neurons: effects of diurnal and nocturnal spontaneous waking, stress and hypocretin-1 administration. Neuroscience, 121:201-217.
Stalnaker TA and Berridge CW (2003) AMPA Receptor stimulation within the central nucleus of the amygdala elicits a differential activation of central dopaminergic systems. Neuropsychopharmacology, 28:1923-1934.
España RA, Reis KM, Valentino RJ, and Berridge CW (2005) Organization of Hypocretin Efferents to Locus Coeruleus and Basal Forebrain Arousal-Related Structures. Journal of Comparative Neurology, 481:160-178.
Vittoz NM and Berridge CW (2006) Hypocretin selectively increases dopamine efflux within the prefrontal cortex. Neuropsychopharmacology, 31:384-395.
Berridge CW, Devilbiss DM, Andrzejewski ME, Arnsten AFT, Kelley AE, Schmeichel B, Hamilton C, Spencer RC (2006) Methylphenidate preferentially increases catecholamine neurotransmission within the prefrontal cortex at low doses that enhance cognitive function. Biological Psychiatry, 60:1111-1120.
Berridge CW (2006) Neural Substrates of Psychostimulant-Induced Arousal. Neuropsychopharmacology, 31:2332-2340.
Devilbiss DM, Berridge CW (2008) Cognition-enhancing doses of methylphenidate preferentially increase prefrontal cortex neuronal responsivity. Biological Psychiatry, 64:626-635.
Stalnaker TA, España RE, Berridge CW. (2009) Coping behavior causes asymmetric changes in neuronal activation in the prefrontal cortex and amygdala. Synapse, 63:82-85.
Berridge CW, Devilbiss DM (2010) Psychostimulants as Cognitive Enhancers: The Prefrontal Cortex, Catecholamines and Attention Deficit Hyperactivity Disorder. Biological Psychiatry, 69: e101- e111.
Spencer RC, Klein, R, Berridge CW (2011) Psychostimulants Act within the Prefrontal Cortex to Improve Cognitive Function. Biological Psychiatry, doi:10.1016/j.biopsych.2011.12.002.
Berridge CW, Shumsky JS, Andrzejewski ME, Devilbiss DM, Spencer RC, Waterhouse BD. (2012) Differential sensitivity to psychostimulants across prefrontal cognitive tasks: differential involvement of noradrenergic α1- and α2-receptors. Biological Psychiatry, 71:467-473. PMCID: PMC3233638. E-Published 2011.
Berridge CW, Schmeichel BE, España RA (2012) Noradrenergic regulation of sleep/wake state. Sleep Medicine Reviews, 16:187-197.
Laboratory Web Site
University of Wisconsin
Department of Psychology
525 W.J. Brogden Building
1202 West Johnson Street
Madison, WI 53706