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Craig Berridge
Curriculum Vitae



  1. Dunn, AJ and Berridge, CW (1987) Behavioral tests -- their interpretation and significance in the study of peptide action. In: Neuromethods, Vol. 6: Peptides (Edited by AA. Boulton, G.B. Baker and Q.J. Pittman), New Jersey: Humana Press.

  2. Dunn, AJ, Elfvin, KL and Berridge, CW (1987) Changes in cerebral biogenic amine metabolism during passive avoidance behavior in mice. In: Learning and Memory: Mechanisms of Information Storage in the Nervous System (Edited by H. Matthies), Oxford: Pergamon Press. pp. 315-324.

  3. Dunn, AJ, Berridge, CW, Lai, YI, Yachabach, TL and File, SE (1988) Corticotropin-releasing factor-induced excessive grooming behavior in rats and mice. Ann. N.Y. Acad. Sci. 525:391-393.

  4. Berridge, CW and Dunn, AJ (1989) Norepinephrine-stimulated CRF release mediates stress-induced changes in exploratory behavior. In: Molecular Biology of Stress. UCLA Symposia on Molecular and Cellular Biology, Vol. 97 (Edited by O. Zinder and S. Breznitz), New York, NY: Allan R. Liss.

  5. Dunn, AJ and Berridge, CW (1990) Is corticotropin-releasing factor a mediator of stress responses? Ann. N.Y. Acad. Sci.: 579:183-191.

  6. Foote, SL, Berridge, CW, Adams, LM and Pineda, JA (1991) Electrophysiological evidence for the involvement of the locus coeruleus in alerting, orienting, and attending. In: Progress in Brain Research, Vol. 88. (Edited by C.D. Barnes and O. Pompeiano), Amsterdam: Elsevier Science Publishers BV. pp. 521-532.

  7. Berridge, CW, Arnsten, AFT, and Foote, SL (1993) Noradrenergic modulation of cognitive function: clinical implications of anatomical, electrophysiological, and behavioral studies in animal models. Psychological Medicine. 23:557-564. (Solicited Editorial).

  8. Berridge, CW (1997) Modulation of forebrain electroencephalographic activity and behavioral state by the locus coeruleus-noradrenergic system: Involvement of the medial septal area. In: Advances in Pharmacology, Vol. 2. (Ed. David Goldstein), Cambridge, MA: Academic Press, pp. 744-748.

  9. Berridge, CW (2001) Attention- and Arousal-Related Actions of the Locus Coeruleus-Noradrenergic System: Potential Target in the Therapeutic Actions of Amphetamine-Like Stimulants. In: The Neuropharmacology of Psychostimulant Drugs: Implications for ADHD, Solanto, M., Arnsten A.F.T., Castalleno, X. eds. pp. 158-184.

  10. Berridge, CW, España, RA and Stalnaker, TA (2002) Stress and Coping: Lateralization of Dopamine Systems Projecting to the Prefrontal Cortex. In: Brain Asymmetry, 2nd Edition (K. Hugdahl, R.J. Davidson, eds.), MIT Press, pp, 69-104.

  11. Berridge, CW (2002) Pharmacological Investigations of Amphetamine-Induced Arousal: Noradrenergic Mechanisms. In: Methods in Drug Abuse Research: Cellular and Circuit Level Analysis. (B. Waterhouse, ed.), CRC Press, Boca Raton, pp. 240-270.

  12. Berridge, CW (2005) The Locus Coeruleus-Noradrenergic System as a Modulator of Arousal State and State-Dependent Behavioral Processes in Stress. In: Handbook on Stress, Immunology and Behaviour, (Eds. T. Steckler, N. Kalin, H. Reul), pp, 437-464.

  13. Berridge, CW and España RA (2005) Hypocretin/Orexin in Stress and Arousal. In: Hypocretins as Integrators of Physiological Signals. (Eds., L. de Lecea and J. G. Sutcliffe). New York, Kluwer Academic/Plenum Publishers, 351-365.

  14. Berridge, CW (2009) The Locus Coeruleus-Noradrenergic System in Stress and Arousal. In: Neurobiology of PTSD (eds. P Shiromani, Ph.D, T Keane, Ph.D, J LeDoux). Humana Press, Inc., Totowa, NJ. pps. 213-230.

  15. Berridge, CW, Devilbiss DM, Spencer RC, Schmeichel BE, Arnsten AFT. (2012) Attention Deficit Hyperactivity Disorder. In: Translational Neuroscience: Applications in Psychiatry, Neurology and Neurodevelopmental Disorders, (J Barrett, J Coyle, M Williams, eds), Cambridge University Press.

  16. Arnsten AFT, Berridge, CW (2015) Catecholamine Influences on Prefrontal Cortex Circuits and Function. In: Attention-Deficit Hyperactivity Disorder in Adults and Children, eds. L. Adler, T. Spencer and T. Wilens. Cambridge University Press.

  17. Berridge, CW, Spencer RC Noradrenergic Control of Arousal and Stress. In: Handbook of Stress Vol 2 : Neuroendocrinology and Endocrinology, ed. G. Fink. Elsevier, Amsterdam.

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Peer-Reviewed Articles

  1. Arnsten, AFT, Berridge, CW, Segal, DS (1985) Stress produces opioid-like effects on investigatory behavior. Pharmacology Biochemistry and Behavior 22:803-809.

  2. Berridge, CW and Dunn, AJ (1986) Corticotropin-releasing factor elicits naloxone sensitive stress-like alterations in exploratory behavior in mice. Regulatory Peptides 16:83-93.

  3. Dunn, AJ, Elfvin, KL and Berridge, CW (1986) Changes in plasma corticosterone and cerebral biogenic amine catabolites during training and testing of mice in passive avoidance behavior. Behavioral and Neural Biology 46:410-423.

  4. Berridge, CW and Dunn, AJ (1987) A corticotropin-releasing factor antagonist reverses the stress-induced changes of exploratory behavior in mice. Hormones & Behavior 21:393-401.

  5. Dunn, AJ, Berridge, CW, Lai, YI, and Yachabach, TL (1987) CRF-induced excessive grooming behavior in rats and mice. Peptides 8:841-844.

  6. Dunn, AJ and Berridge, CW (1987) Corticotropin-releasing factor administration elicits a stress-like activation of cerebral catecholaminergic systems. Pharmacology Biochemistry and Behavior. 27:685-691.

  7. Berridge, CW and Dunn, AJ (1987) Alpha-noradrenergic agonists and antagonists alter exploratory behavior in mice. Neuroscience Research Communications. 1(2):97-103.

  8. Berridge, CW and Dunn, AJ (1989) Restraint-stress-induced changes in exploratory behavior appear to be mediated by norepinephrine-stimulated release of CRF. Journal of Neuroscience. 9(10):3513-3521.

  9. Berridge, CW and Dunn, AJ (1989) Depletion of cerebral norepinephrine in mice using DSP-4 produces opposite effects on exploratory behavior at 3 and 14 days following treatment. Psychopharmacology. 100:504-508.

  10. Berridge, CW and Dunn, AJ (1989) CRF and restraint-stress decrease exploratory behavior in hypophysectomized mice. Pharmacology Biochemistry and Behavior. 34:517-519.

  11. Spadaro, F, Berridge, CW, Baldwin, HE and Dunn, AJ (1990) Corticotropin-releasing factor acts via a third ventricle site to reduce exploratory behavior in rats. Pharmacology Biochemistry and Behavior. 36:305-309.

  12. Dunn, AJ and Berridge, CW (1990) Physiological and behavioral responses to corticotropin-releasing factor administration: is CRF a mediator of anxiety or stress responses? Brain Research Reviews. 15:71-100.

  13. Berridge, CW and Foote, SL (1991) Effects of locus coeruleus activation on electroencephalographic activity in neocortex and hippocampus. Journal of Neuroscience. 11:3135-3145.

  14. Bradberry, CW, Gruen, RJ, Berridge, CW, and Roth, RH (1991) Individual differences in behavioral measures: Correlations with nucleus accumbens dopamine measured by microdialysis. Pharmacology Biochemistry and Behavior. 39:877-882.

  15. Moghaddam, B, Berridge, CW, Goldman-Rakic, PS, Bunney, BS, Roth, RH (1993) In vivo assessment of basal and drug-induced dopamine release in cortical and subcortical regions of the anesthetized primate. Synapse, 13:215-222.

  16. Berridge, CW, Page, M, Valentino, RJ, and Foote, SL (1993) Effects of locus coeruleus inactivation on forebrain electroencephalogragaphic activity. Neuroscience, 55:381-393.

  17. Page, ME, Berridge, CW, Foote, SL, Valentino, RJ (1993) Corticotropin-releasing factor in the locus coeruleus mediates EEG activation associated with hypotensive stress. Neuroscience Letters, 164:81-84.

  18. Davis, M, Hitchcock, JM, Bowers, MB, Berridge, CW, Melia, KR, and Roth, RH (1994) Stress-induced activation of prefrontal cortex dopamine turnover: blockade by lesions of the amygdala. Brain Research, 664:207-210.

  19. Berridge, CW and Foote, SL (1994) Locus Coeruleus-induced modulation of forebrain lectroencephalographic state. Brain Research Bulletin. 35:597-605.

  20. Berridge, CW, Bolen, SJ, Manley, MS and Foote, SL (1996) Modulation of forebrain electroencephalographic (EEG) activity in the halothane-anesthetized rat via actions of noradrenergic β-receptors located within the medial septal region of the basal forebrain. Journal of Neuroscience, 16:7010-7020.

  21. Berridge, CW and Foote, SL (1996) Enhancement of behavioral electroencephalographic (EEG), and electromyographic (EMG) indices of waking following stimulation of noradrenergic β-receptors located within the medial septal region of the basal forebrain in the unanesthetized rat. Journal of Neuroscience, 16:6999-7009.

  22. Berridge, CW, Stratford, T, Foote, SL, Kelley, AE (1997) Localization of DBH-like immunoreactive fibers within the shell of the nucleus accumbens. Synapse, 27:230-241.

  23. Berridge, CW, Mitton, E, and Roth, RH (1999) Selective suppression of the stressor-induced activation of the prefrontal cortical dopamine system by engagement in a behavioral coping response. Synapse, 32:187-197.

  24. Berridge, CW, O’Neil, J, and Wifler, K (1999) Amphetamine Acts Within the Basal Forebrain to Intitiate and Maintain Alert Waking. Neuroscience, 93:885-896.

  25. Weninger, SC, Dunn, AJ, Muglia, LJ, Dikkes, P, Miczek, KA, Swiergiel, AH, Berridge, CW, and Majzoub, J.A. (1999) Stress-induced behaviors require the CRH receptor, but not CRH. Proc. Natl. Acad. Sci. USA 96:8283-8288.

  26. Berridge, CW and Abercrombie, ED (1999) Relationship between locus coeruleus neuronal discharge rate and rates of norepinephrine efflux in cortex. Neuroscience, 93:1263-1270.

  27. Berridge, CW and Morris, M (2000) Noradrenergic β-receptor blockade prevents arousal-enhancing actions of amphetamine on forebrain EEG. Psychopharmacology, 148:307-313.

  28. Berridge, CW and Wifler, K (2000) Contrasting effects in anesthetized and unanesthetized rat of noradrenergic β-receptor blockade within the medial septal area on forebrain EEG and behavioral activity state. Neuroscience, 97:543-552.

  29. Berridge, CW and España, RA (2000) Synergistic actions of β- and α1-noradrenergic receptors in the maintenance of alert waking. Neuroscience, 99:495-505.

  30. Berridge, CW and O’Neill, J (2001) Differential Sensitivity to the Wake-Promoting Actions of Norepinephrine Within the Medial Preoptic Area and the Substantia Innominata. Behavioral Neuroscience, 115:165-174.

  31. España, RA, Baldo B, Kelley AE, Berridge, CW (2001) Wake-Promoting and Sleep-Suppressing Actions of Hypocretin (Orexin): Basal Forebrain Sites of Action. Neuroscience, 106:699-715.

  32. Lin HS, Arai AC, España RA, Berridge, CW, Leslie F, Huguenard J, Vergnes M, Civelli O (2002) Prolactin-Releasing Peptide (PrRP) promotes awakening and suppresses absence seizures. Neuroscience, 114:229-238

  33. España RA, Plahn S, and Berridge, CW (2002) Circadian-Dependent and Circadian-Independent Behavioral Actions of Hypocretin/Orexin. Brain Research, 943:224-236.

  34. Berridge, CW and Stalnaker TA (2002) Relationship between low-dose amphetamine-induced arousal and extracellular norepinephrine and dopamine levels within prefrontal cortex. Synapse, 46:140-149.

  35. Berridge, CW, Isaac S, and España, RA (2003) Additive wake-promoting actions of medial basal forebrain noradrenergic α1- and β-receptor stimulation. Behavioral Neuroscience, 117:350-359.

  36. Berridge, CW and Waterhouse BD (2003) Modulatory Actions of the Locus Coeruleus-Noradrenergic System on Behavioral State and State-Dependent Cognitive Processes. Brain Research Reviews 42:33-84. (Review Article).

  37. España RA, Valentino RJ, and Berridge, CW (2003) Fos immunoreactivity in hypocretin-synthesizing and hypocretin 1-receptor-expressing neurons: effects of diurnal and nocturnal spontaneous waking, stress and hypocretin-1 administration. Neuroscience, 121:201-217.

  38. Baldo BA, Daniel RA, Berridge, CW, and Kelley AE (2003) Overlapping distribution of orexin-containing fibers and dopamine β-hydroxylase-containing fibers in rat brain regions involved in stress and arousal: an immunohistochemical analysis. Journal Comparative Neurology, 464:220-237.

  39. Stalnaker TA and Berridge, CW (2003) AMPA Receptor stimulation within the central nucleus of the amygdala elicits a differential activation of central dopaminergic systems. Neuropsychopharmacology, 28:1923-1934.

  40. Isaac SO and Berridge, CW (2003) Wake-promoting actions of D1 and D2 receptor stimulation. Journal of Pharmacological and Experimental Therapeutics, 307:386-394.

  41. A.J. Barbier, C. Berridge, C. Dugovic, A. Laposky, S.J. Wilson, J. Boggs, L. Aluisio, B. Lord, C. Mazur, C.M. Pudiak, X. Langlois, W. Xiao, R. Apodaca, N.I. Carruthers, T.W Lovenberg (2004) Wake-promoting effect of JNJ-5207852, a novel, diamine-based H3 antagonist. British Journal of Pharmacology, 143:649-661.

  42. R. A. España, C. W. Berridge and S. C. Gammie (2004) Lactation-associated alterations in Fos immunoreactivity within hypocretin-synthesizing neurons and neurons in MPOA and LC. Peptides, 25:1927-1934.

  43. España RA, Reis KM, Valentino RJ, and Berridge CW (2005) Organization of hypocretin efferents to locus coeruleus and basal forebrain arousal-related structures. Journal of Comparative Neurology, 481:160-178.

  44. Berridge, CW, Stellick R and Schmeichel (2005) Wake-promoting actions of medial basal forebrain β2-receptor stimulation. Behavioral Neuroscience, 119:743-751.

  45. Berridge, CW and España RA (2005) Hypocretins: Waking, Arousal or Action? Neuron, 46:696-698.

  46. Dvorak CA, Apodaca R, Barbier AJ, Berridge, CW, Wilson SJ, Boggs JD, Xiao W, Lovenberg TW and Carruthers NI (2005) 4-Phenoxypiperidines: Potent, conformationally restricted, non-imidazole histamine H3 antagonists. Journal of Medicinal Chemistry, 48:2229-2238.

  47. Vittoz NM and Berridge, CW (2006) Hypocretin selectively increases dopamine efflux within the prefrontal cortex. Neuropsychopharmacology, 31:384-395.

  48. Mill J, Caspi A, Williams BS, Craig I, Taylor A, Polo-Tomas M, Berridge, CW, Poulton R, Moffitt TE (2006) Genetic polymorphisms in the dopamine system predict heterogeneity in intelligence and adult prognosis among children with attention-deficit hyperactivity disorder: Evidence from two birth cohorts. Archives of General Psychiatry, 63:462-469.

  49. España RA, and Berridge, CW (2006) Organization of locus coeruleus efferents to basal forebrain arousal-related structures. Journal of Comparative Neurology, 496:668-683.

  50. Berridge, CW, Devilbiss DM, Andrzejewski ME, Arnsten AFT, Kelley AE, Schmeichel B, Hamilton C, Spencer RC (2006) Methylphenidate preferentially increases catecholamine neurotransmission within the prefrontal cortex at low doses that enhance cognitive function. Biological Psychiatry, 60:1111-1120.

  51. Berridge, CW (2006) Neural Substrates of Psychostimulant-Induced Arousal. Neuropsychopharmacology, 31:2332-2340. Review article.

  52. Devilbiss DM and Berridge, CW (2006) Actions of low-dose methylphenidate (Ritalin) on tonic and phasic locus coeruleus discharge. Journal of Pharmacological and Experimental Therapeutics, 319:1327-1335. PMC3049261.

  53. Conti LH, Berridge, CW, Tayler JE. (2006) Both Corticotropin-Releasing Factor and Apomorphine Reduce Prepulse Inhibition Following Repeated Central Infusion of Corticotropin-Releasing Factor. Pharmacology, Biochemistry and Behavior, 85:261-272.

  54. Berridge, CW (2008) Noradrenergic Modulation of Arousal. Brain Research Reviews, 58:1-17. PMC2517724.

  55. Vittoz N, Schmeichel B, Berridge, CW (2008) Hypocretin/Orexin Activates Prefrontal Cortex- and Nucleus Accumbens Shell-Projecting Dopamine Neurons Within the Caudomedial Ventral Tegmental Area. European Journal of Neuroscience, 28:1629-1640.

  56. Devilbiss DM, Berridge, CW (2008) Cognition-enhancing doses of methylphenidate preferentially increase prefrontal cortex neuronal responsivity. Biological Psychiatry, 64:626-635. PMC2603602.

  57. Stalnaker TA, España RE, Berridge, CW. (2009) Coping behavior causes asymmetric changes in neuronal activation in the prefrontal cortex and amygdala. Synapse, 63:82-85.

  58. Arnsten AFT, Berridge, CW, McCracken J (2009) The Neurobiological Basis of Attention Deficit Hyperactivity Disorder, Primary Psychiatry, 16:47-54.

  59. Berridge, CW, España RE, Vittoz N. (2010) Hypocretin/Orexin in Stress and Arousal. Brain Research, 1314:91-102. Invited review for special issue. PMC2819651.

  60. Berridge, CW, Devilbiss DM (2010) Psychostimulants as Cognitive Enhancers: The Prefrontal Cortex, Catecholamines and Attention Deficit Hyperactivity Disorder. Biological Psychiatry, 69: e101- e111. Invited review for special issue. PMCID: PMC3012746.

  61. Agster L, Clark BD, Gao W-J, Shumsky JS, Wang H-X, Berridge, CW, and Waterhouse BD (2011) Experimental strategies for investigating psychostimulant drug actions and prefrontal cortical function in ADHD and related attention disorders. Anatomical Record, 294:1698–1712.

  62. Berridge, CW, Shumsky JS, Andrzejewski ME, Devilbiss DM, Spencer RC, Waterhouse BD. (2012) Differential sensitivity to psychostimulants across prefrontal cognitive tasks: differential involvement of noradrenergic α1- and α2-receptors. Biological Psychiatry. 71:467-473. PMCID: PMC3233638. E-Published 2011.

  63. Spencer RC, Klein, R, Berridge, CW (2011) Psychostimulants Act within the Prefrontal Cortex to Improve Cognitive Function. Biological Psychiatry, 72:221-227.

  64. Berridge, CW, Schmeichel BE, España RA (2012) Noradrenergic regulation of sleep/wake state. Sleep Medicine Reviews, 16:187-197. (Invited contribution, peer-reviewed).

  65. Devilbiss DM, Waterhouse BD, Valentino R, Berridge, CW (2012) Corticotropin Releasing Factor Acting at the Locus Coeruleus Disrupts Sensory Signaling. Neuropsychopharmacology, 37:2020:2030.

  66. Devilbiss DM, Jenison R, Berridge CW (2012) Stress-Induced Impairment of a Working Memory Task: Role of Spiking Rate and Spiking History Predicted Discharge. PLoS Computational Biology, 8(9): doi:10.1371/journal.pcbi.1002681.

  67. Berridge, CW, Arnsten AFT (2013) Psychostimulants and Motivated Behavior: Arousal and Cognition. Neuroscience and Biobehavioral Reviews, 37:1976-1984.

  68. Schmeichel B, Zemlan F, Berridge CW (2013) A Selective dopamine reuptake inhibitor improves prefrontal cortex-dependent cognitive function: Potential relevance to attention deficit hyperactivity disorder. Neuropharmacology, 64:321-328.

  69. Schmeichel B, Berridge CW (2013) Wake-Promoting Actions of Noradrenergic α1- and β-Receptors within the Lateral Hypothalamic Area. European Journal of Neuroscience, 37:891-900.

  70. Schmeichel BE, Berridge, CW (2013) Neurocircuitry Underlying the Preferential Sensitivity of Prefrontal Catecholamines to Low-Dose Psychostimulants. Neuropsychopharmacology. 38:1078-1084. PMCID: PMC3629407.

  71. Schmeichel BE, Berridge, CW (2014) Amphetamine acts within the lateral hypothalamus to elicit affectively neutral arousal and reinstate drug seeking. International Journal of Neuropsychopharmacology, 17-63-75.

  72. Andrzejewski ME, Spencer RC, Harris RL, Feit EC, McKee BL, Berridge CW (2014) The effects of clinically relevant doses of amphetamine and methylphenidate on signal detection and DRL in rats. Neuropharmacology. 79:634-41.

  73. Spencer RC, Devilbiss DM, Berridge CW (2014) The cognition-enhancing effects of psychostimulants involve direct action in the Prefrontal Cortex. Biological Psychiatry, 77:940-950. Invited Review (based on Spencer et al. 2012 annual citation count).

  74. Berridge CW, Arnsten AFT (2015) Catecholamine mechanisms in the prefrontal cortex: proven strategies for enhancing higher cognitive function. Current Opinion in Behavioral Sciences, 4:33-40.

  75. Berridge CW Spencer RC. Differential Cognitive Actions of Norepinephrine α2 and α1 Receptor Signaling in the Prefrontal Cortex. Brain Research, pii: S0006-8993(15)00868-9. doi: 10.1016/j.brainres.2015.11.024. epub ahead of print. Invited Review for Special Issue.

  76. Berridge CW, Schmeichel BE, España RA Norepinephrine at the Nexus of Arousal, Motivation and Relapse. Brain Research, in press. Invited Review

  77. Devilbiss DM, Spencer RC, Berridge CW. Stress Impairs Goal-Directed Coding of Prefrontal Cortex Neurons. Submitted

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