Phone: (608) 265-8722
Office: 589 Psychology
Laboratory of Neurophysiological Modulation and Behavior
NexStep Biomarkers Home Page
(Not Afiliated with the University of Wisconsin)
David M. Devilbiss
Ph.D. 2002, Drexel University
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My research continues to focus on understanding the interaction between central monoamine and neuropeptide systems,
their modulation of individual neuron and distributed neural coding, and its relation to cognitive and behavioral changes.
Most recently my focus has been to examine 1) the neural mechanisms responsible for the cognition-enhancing effects of
methylphenidate (Ritalin) and 2) the neural mechanisms underlying stress-related behavioral changes. Several challenges
exist with this line of research including identifying putative distributed neural codes that undergo neuromodulation,
which reflect cognitive, behavioral, and/or perceptual changes.
To address these questions I am continually developing behavioral assays for rodents that will permit simultaneous electrophysiological
recordings of dozens of neurons engaged in coding those behavioral tasks. Additionally, I am continally developing and refining
statistical approaches to analyzing multiple simultaneous recordings as well as developing computer science based solutions for
linking data warehousing and information management. This work involves collaborations with researchers at Drexel University,
University of Pennsylvania, as well as Drs. RL Jenison and CW Berridge.
Devilbiss DM, RL Jenison, Berridge CW. Stress-Induced Impairment of a Working Memory Task: Role of Spiking Rate and Spiking History Predicted Discharge. PLoS Computational Biology 2012 8(9);e1002681
Devilbiss DM, Waterhouse BD, Berridge CW, Valentino R.. Corticotropin-releasing factor acting at the locus coeruleus disrupts thalamic and cortical sensory-evoked responses. Neuropsychopharmacology 2012 Aug;37(9):2020-30
Devilbiss DM, Waterhouse BD. Phasic and tonic patterns of locus coeruleus output differentially modulate sensory network function in the awake rat.J Neurophysiol. 2011 Jan;105(1):69-87.
Leiser SC, Dunlop J, Bowlby MR, Devilbiss DM. Aligning strategies for using EEG as a surrogate biomarker: a review of preclinical and clinical research.Biochem Pharmacol. 2011 Jun 15;81(12):1408-21
Berridge CW, Devilbiss DM. Psychostimulants as cognitive enhancers: the prefrontal cortex, catecholamines, and asttention-deficit/hyperactivity disorder.Biol Psychiatry. 2011 Jun 15;69(12):e101-11