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Craig Berridge
Professor, Department of Psychology
Ph.D. 1988, University of Florida
Email: berrdige@wisc.edu
My research focuses on the actions of certain neurotransmitters in the regulation of behavioral state and state-dependent cognitive processes (working memory, attention). Specifically, we are interested in the catecholamine (i.e. dopamine, norepinephrine) and certain peptide neurotransmitters (CRF, hypocretin) and their actions under normal and high-arousal (i.e. stress) conditions. Currently there are 4 main themes: 1) Neurobiology of Waking; 2) Neural Mechanisms of Amphetamine-Induced Arousal; 3) Neurobiology of Low-Dose Methylphenidate (Ritalin); Relevance to ADHD; 4) Neurobiology of stress and coping. Recent work begins to examine the actions of low-dose methylphenidate, hypocretin and CRF on prefrontal cortex-dependent cognition and prefrontal cortical neuronal activity. These latter studies utilize multiple single-unit electrophysiological recordings in freely-moving animals (rats). We take a multidisciplinary approach
in which a variety of methods are utilized, including pharmacological, electrophsyiological, anatomical, and neurochemical techniques.
Representative Publications
Berridge CW, Foote SL (1996) Enhancement of behavioral, electroencephalographic (EEG), and electromyographic
(EMG) indices of waking following stimulation of noradrenergic b-receptors located within the medial septal region of the basal forebrain in the unanesthetized rat. Journal of Neuroscience, 16:6999-7009.
Berridge CW and Waterhouse BD (2003) Modulatory Actions of the Locus Coeruleus-Noradrenergic System on Behavioral State and State-Dependent Cognitive Processes. Brain Research Review 42:33-84.
Stalnaker TA and Berridge CW (2003) AMPA Receptor stimulation within the central nucleus of the amygdala elicits a differential activation of central doopaminergic systems. Neurophyschopharmachology, 28:1923-1934.
Epana RA, Reis KM, Valentino RJ, and Berridge CW (2005) Organization of Hyocretin Efferents to Locus Coeruleus and Basal Forebrain Arousal-Related Structures. Journal of Comparative Neurology, 481:160-178.
Vittoz NM and Berridge CW (2005) Hypocretin/Orexin seletively increases dopamine efflux within the prefrontal cortex: involvement of the ventral tegmental area. Neuropsychopharmacology, 31:384-395
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