Diane Carol Gooding

Research Area(s)
Clinical
Biology of Brain and Behavior

Dr. Gooding’s Website
Dr. Diane Gooding.com

Lab Website
Paths Lab

Research Interests

Overall, my research focus is on detecting risk for brain disorders, whether schizophrenia and schizophrenia-spectrum disorders (SSDs) or Alzheimer’s disease and related disorders (AD/ADRD).

My research program encompasses identification and validation of endophenotypic markers, predictors, ad precursors of liability for SSDs.  My lab accomplishes the early identification and longitudinal study of the development of psychosis using various research approaches (i.e., psychometric, genetic, clinical high-risk strategies), and methods (e.g., psychophysiological, neurocognitive, biobehavioral, and clinical assessment).

A second but equally fulfilling line of research involves the study of preclinical biomarkers and other indicators of risk for cognitive decline and neurodegenerative disorders, particularly in underrepresented communities.  Through initiatives such as the Understanding Biomarker and Genetic Research (UBIGR) Project and the African-Americans Fighting Alzheimer’s Disease in Midlife (AA-FAIM) Project, I have worked collaboratively to examine whether scientific advances made in AD/ADRD are generalizable to more diverse groups.  Our lab group is also at the forefront of contributing to new insights and strategies in the science of recruitment and retention.

Representative Publications

Gooding, D.C., *Tallent, K.A., & Matts, C.W. (2005). Clinical status of at-risk individuals five years later: Further validation of the psychometric high-risk strategy. Journal of Abnormal Psychology, 114, 170-175.

Gooding, D.C., Ott, S., Roberts, S.A., & Erlenmeyer-Kimling, L. (2013). Thought disorder in mid-childhood as a predictor of adulthood diagnostic outcome: Findings from the New York High-Risk Project. Psychological Medicine, 43(5), 1003-1012. doi:10.1017/S0033291712001791.

Gooding, D.C. & Pflum, M. J. (2014). The assessment of interpersonal pleasure: Introduction of the Anticipatory and Consummatory Interpersonal Pleasure Scale (ACIPS) and preliminary findings. Psychiatry Research, 215 (1), 237-243.

Gleason, C.E., Zuelsdorff, M., Gooding, D.C., Kind AJK, Johnson AL, James TT, Lambrou NH, Wyman MF, Ketchum FB, Gee A, Johnson SC, Bendlin BB, Zetterberg H.  (2022).  Alzheimer’s disease biomarkers in Black and non-hispanic White cohorts:  A contextualized review of the evidence.  Alzheimer’s & Dementia, 18, 1545-1564. https://alz-journals.onlinelibrary.wiley.com/doi/full/10.1002/alz.12511

Gooding, D.C. (2023). Social anhedonia and other indicators of risk for schizophrenia: Theory and inquiry.  Special issue:  Celebrating the accomplishments of thought leaders in psychiatry research. Psychiatry Research, 319, 114966.

Fischer, B.L., Van Hulle, C.A., Norton, D.L., Wyman, M.F., Ennis, G., Lambrou, N.H., Bouges, S., Gooding, D.C., & Gleason, C.E.  (2025). Mild Behavioral Impairment is associated with incident cognitive decline among dementia-free, racially diverse older adults: Data from the African Americans Fighting Alzheimer’s in Midlife (AA-FAIM) study. American Journal of Geriatric Psychiatry: Open Science, Education, and Practice, 8:C:43-53.

Gooding, D.C., Carter, F.P., Zuelsdorff, M.., Gee, A., Anthony, R.L., Boustead, B., Russell, T., Chin, N.A., Clark, C., Cornelius, K., Asthana, S., Johnson, S.C., & Gleason, C.E.  Guided by the Community”:  Insights on Recruitment Science from the AA-FAIM Project. (2025).  Alzheimer’s & Dementia: Behavior & Socioeconomics of Aging (A&D: BSEA). e70008.https://doi.org/10.1002/bsa3.70008