Department of Psychology

Craig Berridge

Position title: The Patricia Goldman-Rakic Professor of Psychology

Email: berridge@wisc.edu

Phone: (608) 265-5938

Address:
525 Psychology

Research Area(s)
Biology of Brain and Behavior

Lab Website
Neural Systems and Behavior Lab

Research Interests
My research focuses on the neurobiology of stress, arousal and cognitive enhancers used in the treatment of ADHD. We take a multidisciplinary approach that includes anatomical, neurochemical, behavioral, electrophysiological, computational and, most recently, viral vector-based ontogenetic and chemogenetic methods. Much of our current work is focused on understanding the neurotransmitter and circuit mechanisms through which ADHD-related drugs and stress alter higher cognitive function dependent on the prefrontal cortex and extended frontostriatal circuitry.

Representative Publications

Neurobiology of ADHD-Related Cognitive Enhancers

  1. Berridge, CW, Arnsten AFT (2013) Psychostimulants and Motivated Behavior: Arousal and Cognition. Neuroscience and Biobehavioral Reviews, 37:1976-1984. http://www.ncbi.nlm.nih.gov/pubmed/?term=Berridge+Arnsten+2013
  2. Schmeichel BE, Berridge, CW (2013) Neurocircuitry Underlying the Preferential Sensitivity of Prefrontal Catecholamines to Low-Dose Psychostimulants. Neuropsychopharmacology. 17:63-75.
  3. Spencer RC, Klein, R, Berridge CW (2012) Psychostimulants Act within the Prefrontal Cortex to Improve Cognitive Function. Biological Psychiatry, 72:221-227.
  4. Berridge CW, Shumsky JS, Andrzejewski ME, Devilbiss DM, Spencer RC, Waterhouse BD (2012) Differential sensitivity to psychostimulants across prefrontal cognitive tasks: differential involvement of noradrenergic α1- and α2-receptors. Biological Psychiatry. 71(5):467-73.
  5. Devilbiss DM, Berridge CW (2008) Cognition-enhancing doses of methylphenidate preferentially increase prefrontal cortex neuronal responsivity. Biological Psychiatry, 64:626-635.
  6. Berridge CW, Devilbiss DM, Andrzejewski ME, Arnsten AFT, Kelley AE, Schmeichel B, Hamilton C, Spencer RC (2006) Methylphenidate preferentially increases catecholamine neurotransmission within the prefrontal cortex at low doses that enhance cognitive function. Biological Psychiatry, 60:1111-1120.

Neurobiology of Prefrontal Cortex-Dependent Cognition

  1. Devilbiss DM, Spencer RC, Berridge CW (2016): Stress Degrades Prefrontal Cortex Neuronal Coding of Goal-Directed Behavior.  Cerebral Cortex. doi: 10 1093/cercor/bhw140, epub ahead of print
  2. Hupalo S, Berridge CW (2016): Working Memory Impairing Actions of Corticotropin-Releasing Factor (CRF) Neurotransmission in the Prefrontal Cortex.  Neuropsychopharmacology. doi:10.1038/npp.2016.85. epub ahead of print
  3. Devilbiss DM, Jenison R, Berridge CW (2012) Stress-Induced Impairment of a Working Memory Task: Role of Spiking Rate and Spiking History Predicted Discharge. PLoS Computational Biology, 8(9): doi:10.1371/journal.pcbi.1002681. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3441423/pdf/pcbi.1002681.pdf
  4. Devilbiss DM, Waterhouse BD, Berridge CW, Valentino R (2012) Corticotropin Releasing Factor Acting at the Locus Coeruleus Disrupts Sensory Signaling. Neuropsychopharmacology, 37: 2020-2030.
  5. Stalnaker TA, España RE, Berridge CW. (2009) Coping behavior causes asymmetric changes in neuronal activation in the prefrontal cortex and amygdala. Synapse, 63:82-85.

Neurobiology of Arousal

  1. Schmeichel BE, Berridge, CW (2014) Amphetamine acts within the lateral hypothalamus to elicit affectively-neutral arousal and reinstate drug-seeking. International Journal of Neuropsychopharmacology. 17:63-75.
  2. Schmeichel B, Berridge CW (2013) Wake-Promoting Actions of Noradrenergic α1- and β-Receptors within the Lateral Hypothalamic Area. European Journal of Neuroscience, 37:891-900.
  3. Berridge CW, Schmeichel BE, España RA (2012) Noradrenergic regulation of sleep/wake state. Sleep Medicine Reviews, 16:187-197.
  4. Berridge, CW. Arnsten AFT (2013) Psychostimulants and Motivated Behavior: Arousal and Cognition.  Neuroscience and Biobehavioral Reviews, 37:1976-1984.  Invited review, peer-reviewed.  Impact rating 8.7 (vs. J. Neurosci 7.1).
  5. España RA, and Berridge CW (2006) Organization of locus coeruleus efferents to basal forebrain arousal-related structures. Journal of Comparative Neurology, 496:668-683.
  6. España RA, Reis KM, Valentino RJ, and Berridge CW (2005) Organization of hypocretin efferents to locus coeruleus and basal forebrain arousal-related structures. Journal of Comparative Neurology, 481:160-178.
  7. Berridge CW and Waterhouse BD (2003) Modulatory Actions of the Locus Coeruleus-Noradrenergic System on Behavioral State and State-Dependent Cognitive Processes. Brain Research Review 42:33-44.
  8. España, RA, Baldo B, Kelley AE, Berridge, CW (2001) Wake-Promoting and Sleep-Suppressing Actions of Hypocretin (Orexin): Basal Forebrain Sites of Action. Neuroscience, 106:699-715.
  9. Berridge, CW and Foote, SL (1996) Enhancement of behavioral electroencephalographic (EEG), and electromyographic (EMG) indices of waking following stimulation of noradrenergic -receptors located within the medial septal region of the basal forebrain in the unanesthetized rat. Journal of Neuroscience, 16:6999-7009.
  10. Berridge, CW and Foote, SL (1991) Effects of locus coeruleus activation on electroencephalographic activity in neocortex and hippocampus. Journal of Neuroscience. 11:3135-3145.